Safety, tolerability and pharmacokinetics of rilpivirine following administration of a long-acting formulation in healthy volunteers

Verloes R.; Deleu S.; Niemeijer N.; Crauwels H.; Meyvisch P.; Williams P.

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Safety, tolerability and pharmacokinetics of rilpivirine following administration of a long-acting formulation in healthy volunteers

机译：在健康志愿者中服用长效制剂后，rilpivirine的安全性，耐受性和药代动力学

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摘要

ObjectivesThis phase I healthy volunteer study (NCT01031589) was carried out to investigate the safety/tolerability and pharmacokinetics of a rilpivirine (RPV; TMC278) long-acting (LA) formulation after single and multiple intramuscular (IM) injections.

机译：目的进行第一阶段健康志愿者研究（NCT01031589），以研究单次和多次肌内（IM）注射后利培韦林（RPV; TMC278）长效（LA）制剂的安全性/耐受性和药代动力学。

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《HIV medicine 》 |2015年第8期| 共8页
作者
Verloes R.; Deleu S.; Niemeijer N.; Crauwels H.; Meyvisch P.; Williams P.;
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正文语种 eng
中图分类传染病 ;
关键词
HIV; long-acting formulation; nonnucleoside reverse transcriptase inhibitor; pharmacokinetics; rilpivirine;

机译：HIV;长效制剂;非核苷类逆转录酶抑制剂;药代动力学;利比韦林;

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1. Safety, tolerability and pharmacokinetics of rilpivirine following administration of a long-acting formulation in healthy volunteers [J] . Verloes R., Deleu S., Niemeijer N., HIV medicine . 2015 ,第8期

机译：在健康志愿者中服用长效制剂后，rilpivirine的安全性，耐受性和药代动力学
2. ND0701, A Novel Formulation of Apomorphine for Subcutaneous Infusion, in Comparison to a Commercial Apomorphine Formulation: 28-Day Pharmacokinetic Study in Minipigs and a Phase I Study in Healthy Volunteers to Assess the Safety, Tolerability, Pharmacokinetics and Relative Bioavailability [J] . Ramot Yuval, Nyska Abraham, Adar Liat, CNS drugs . 2018 ,第5期

机译：ND0701是一种新型制剂，用于皮下输注的仲卟啉，与商业扑梅啡制剂相比：MINIPIG的28天药代动力学研究和我在健康志愿者的研究中研究，以评估安全性，耐受性，药代动力学和相对生物利用度
3. Navafenterol (AZD8871) in healthy volunteers: safety, tolerability and pharmacokinetics of multiple ascending doses of this novel inhaled, long-acting, dual-pharmacology bronchodilator, in two phase I, randomised, single-blind, placebo-controlled studies [J] . Victor Balaguer, Muna Albayaty, Eulalia Jimenez, Respiratory Research . 2020 ,第S1期

机译：Navafenterol（AZD8871）在健康的志愿者中：这种新型吸入剂量的多个上升剂量的安全性，耐受性和药代动力学，两阶段I，随机，单盲，安慰剂对照研究中的多种升序，长效，双药理学支气管扩张剂
4. Safety, tolerability, pharmacodynamics and pharmacokinetics following single subcutaneous dosesof a teverelix depot formulation in healthy male volunteers [C] . C. MacLean, F. Larsen, R. Piechatzek, Annual meeting exposition of the Controlled Release Society . 2005

机译：在健康男性志愿者中单次皮下注射Teverelix储库制剂后的安全性，耐受性，药效动力学和药代动力学
5. Pharmacokinetics, tissue depletion, target animal safety and live animal swab test accuracy after administration of long-acting oxytetracycline at double the label dose in healthy calves. [D] . TerHune, Terry Norman. 1988

机译：在健康小牛中，以双倍剂量服用长效土霉素后，药代动力学，组织耗竭，目标动物安全性和活体拭子测试准确性。
6. Navafenterol (AZD8871) in healthy volunteers: safety tolerability and pharmacokinetics of multiple ascending doses of this novel inhaled long-acting dual-pharmacology bronchodilator in two phase I randomised single-blind placebo-controlled studies [O] . Victor Balaguer, Muna Albayaty, Eulalia Jimenez, 2020

机译：Navafenterol（AZD8871）在健康的志愿者中：这种新型吸入剂量的多个上升剂量的安全性耐受性和药代动力学两阶段I随机单盲安慰剂对照研究
7. Safety, tolerability and pharmacokinetics of rilpivirine following administration of a long-acting formulation in healthy volunteers [O] . R Verloes, S Deleu, N Niemeijer, 2015

机译：在健康志愿者施用长效制剂后瑞培的安全性，耐受性和药代动力学

Safety, tolerability and pharmacokinetics of rilpivirine following administration of a long-acting formulation in healthy volunteers

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