miR-503, a microRNA epigenetically repressed in endometriosis, induces apoptosis and cell-cycle arrest and inhibits cell proliferation, angiogenesis, and contractility of human ovarian endometriotic stromal cells

Hirakawa Tomoko; Nasu Kaei; Abe Wakana; Aoyagi Yoko; Okamoto Mamiko; Kai Kentaro; Takebayashi Kanetoshi; Narahara Hisashi

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miR-503, a microRNA epigenetically repressed in endometriosis, induces apoptosis and cell-cycle arrest and inhibits cell proliferation, angiogenesis, and contractility of human ovarian endometriotic stromal cells

机译：miR-503，一种在子宫内膜异位症中被表观遗传抑制的microRNA，可诱导凋亡和细胞周期停滞，并抑制人卵巢子宫内膜异位基质细胞的细胞增殖，血管生成和收缩

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Is the micro-RNA (miRNA) miR-503, downregulated in endometriotic cyst stromal cells (ECSCs) and does this affect the cell cycle, cell proliferation, angiogenesis and contractility of these cells?

机译：子宫内膜异位囊肿基质细胞（ECSC）中的microRNA（miRNA）miR-503是否下调，这会影响这些细胞的细胞周期，细胞增殖，血管生成和收缩力吗？

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《Human Reproduction》 |2016年第11期|共11页
作者
Hirakawa Tomoko; Nasu Kaei; Abe Wakana; Aoyagi Yoko; Okamoto Mamiko; Kai Kentaro; Takebayashi Kanetoshi; Narahara Hisashi;
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正文语种 eng
中图分类人体生理学;
关键词
endometriosis; micro-RNA; cyclin D1; DNA methylation; cell proliferation; apoptosis; cell cycle; angiogenesis; contractility;

机译：子宫内膜异位症;微小RNA;细胞周期蛋白D1;DNA甲基化;细胞增殖;凋亡;细胞周期;血管生成;收缩力;

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1. miR-503, a microRNA epigenetically repressed in endometriosis, induces apoptosis and cell-cycle arrest and inhibits cell proliferation, angiogenesis, and contractility of human ovarian endometriotic stromal cells [J] . Hirakawa Tomoko, Nasu Kaei, Abe Wakana, Human Reproduction . 2016,第11期

机译：miR-503，一种在子宫内膜异位症中被表观遗传抑制的microRNA，可诱导凋亡和细胞周期停滞，并抑制人卵巢子宫内膜异位基质细胞的细胞增殖，血管生成和收缩
2. Arcyriaflavin a, a cyclin D1–cyclin-dependent kinase4 inhibitor, induces apoptosis and inhibits proliferation of human endometriotic stromal cells: a potential therapeutic agent in endometriosis [J] . Tomoko Hirakawa, Kaei Nasu, Yoko Aoyagi, Reproductive Biology and Endocrinology . 2017,第1期

机译：Arcyriaflavin a，细胞周期蛋白D1–细胞周期蛋白依赖性激酶4抑制剂，可诱导人子宫内膜异位基质细胞凋亡并抑制其增殖：子宫内膜异位症的潜在治疗剂
3. Simvastatin inhibits the proliferation and the contractility of human endometriotic stromal cells: a promising agent for the treatment of endometriosis. [J] . Nasu K, Yuge A, Tsuno Fertility and Sterility: Official Journal of the American Fertility Society, Pacific Coast Fertility Society, and the Canadian Fertility and Andrology Society . 2009,第6期

机译：辛伐他汀抑制人子宫内膜异位基质细胞的增殖和收缩：一种用于治疗子宫内膜异位的有前途的药物。
4. Alternol Inhibits Proliferation and Induces Apoptosis in Human Leukemia HL-60 Cells [C] . Chen Ji, Li Defang, Zhang Bo, 5th International Conference on Bioinformatics and Biomedical Engineering . 2011

机译：交替烷抑制人白血病HL-60细胞的增殖并诱导其凋亡。
5. Cannabinol Inhibits Proliferation and Induces Cell Cycle Arrest and Apoptosis in Glioblastoma, Hepatocellular Carcinoma and Breast Cancer Cells [D] . Zhong, Nuanying. 2020

机译：大麻素抑制胶质母细胞瘤，肝细胞癌和乳腺癌细胞中的增殖和诱导细胞周期停滞和凋亡
6. Arcyriaflavin a a cyclin D1–cyclin-dependent kinase4 inhibitor induces apoptosis and inhibits proliferation of human endometriotic stromal cells: a potential therapeutic agent in endometriosis [O] . Tomoko Hirakawa, Kaei Nasu, Yoko Aoyagi, 2017

机译：Arcyriaflavin a细胞周期蛋白D1–细胞周期蛋白依赖性激酶4抑制剂可诱导人子宫内膜异位基质细胞凋亡并抑制其增殖：子宫内膜异位症的潜在治疗剂
7. miR-503, a microRNA epigenetically repressed in endometriosis, induces apoptosis and cell-cycle arrest and inhibits cell proliferation, angiogenesis, and contractility of human ovarian endometriotic stromal cells [O] . Tomoko Hirakawa, Kaei Nasu, Wakana Abe, 2016

机译：miR-503，在子宫内膜异位症中表现出细菌抑制的microRNA，诱导细胞凋亡和细胞周期停滞，抑制人卵巢内膜异位胞间基质细胞的细胞增殖，血管生成和收缩性

miR-503, a microRNA epigenetically repressed in endometriosis, induces apoptosis and cell-cycle arrest and inhibits cell proliferation, angiogenesis, and contractility of human ovarian endometriotic stromal cells

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