Carbonyl stress induces hypertension and cardio-renal vascular injury in Dahl salt-sensitive rats

摘要

Methylglyoxal (MG) is a highly reactive alpha-dicarbonyl compound that is biosynthesized by the glycolysis pathway. MG modifies the lysine and arginine residues of proteins, including radical scavengers,1 and it is a potent precursor of advanced glycation end products (AGEs).2 Plasma MG levels are increased in diabetes patients and in patients with chronic kidney disease (CKD).3 Therefore, MG and its protein adducts have been implicated in the development of chronic diabetes complications, such as retinopathy and nephropathy, and uremia, which are referred to as carbonyl stress.2