Anti-stiffness effect of apocynin in deoxycorticosterone acetate-salt hypertensive rats via inhibition of oxidative stress

摘要

Increasing evidence suggests that large artery stiffness (often measured by pulse wave velocity, PWV)..-predicts cardiovascular events.1 Stiffening of large central arteries, particularly the aorta, occurs during physiological processes such as aging and during pathological processes such as hypertension, diabetes mellitus and end-stage renal disease. It has also been shown that abnormal collagen deposition in the aortic arterial wall contributes to increased arterial stiffness.2,3