Haplotype Reconstruction and Estimation of Haplotype Frequencies from Nuclear Families with One Parent Available and Varying Numbers of Children Using the Exact Likelihood

摘要

Recently we proposed a method for haplotype inference in nuclear families with only one parent available. Our approach, which we call PCHAP (parent-child haplotyping) here for convenience, is exact for families consisting of one parent and one child only, in which parent and child share one haplotype. While the original PCHAP approach was designed to handle a single child only, we suggested as an approximation to handle two children by splitting the one parent and two children in two parent child haplotype pairs treated as independent