Erratum to: Evidence of statistical epistasis between DISC1, CIT and NDEL1 impacting risk for schizophrenia: biological validation with functional neuroimaging.

摘要

Fig. 2 CIT intragenic neuroimaging epistasis. C1T rs3847960 by CIT rs440299 interaction in normal subjects studied with BOLD fMRI during the N back working memory task. Figure at the top shows loci (in yellow) within brain in which significant interaction is found (p < 0.05 corrected) for all voxels within prefrontal cortical region of interest. Image at bottom shows relative degree of activation of DLPFC region showing imaging interaction based on genotypes at these two SNPs [fMRI signal extracted from maximum voxel and run as ANOVA in SPSS yielded F(l,256) = 9.960, p = 0.002]. The combination of both risk associated genotypes is disproportionally inefficient, i.e., have greatest activation without any difference in performance. Error bars represent 1 standard error of the mean. Frontal lobe (sub-gyral) mean activation extracted from 10 mm sphere at (30 37 8) Talairach