Introduction: Gene and Cell Therapy Projects of the Seventh Framework Program

摘要

We present herein the first series of 10 recently finished or ongoing gene therapy projects funded by the European Union during the seventh framework program for research and innovation (2007-2013). The majority of these projects address rare diseases (AIPgene, Genegraft, Cell-PID, OptiStem, Treatrush, PERSIST), while some investigate common disorders such as cancer (LeukoTreat), vascular (Biomagscar), bone (Gamba), or neurological disorders (BrainCAV). These international collaborative projects are multidisciplinary and gather the necessary expertise to progress from bench to bedside. The presentation of each of these projects includes main findings and publications in addition to their dedicated website where details about consortium's structure and achievements can be found. Throughout the years, our funding was targeted to support technological scale-up, good manufacturing practice, development of new and adequate preclinical models to foster new toxicology, and monitoring tests so that the technology could reach the patients. The support to the very innovative clinical trials required to challenge the European ethics and currently evolving regulatory context.