Nuclear reprogrammed cells generated by introduction of a histone H2aa or TH2A gene, a histone H2ba or TH2B gene, or a phosphorylation-mimic of histone chaperon Npm2 gene, an Oct family gene and a klf family gene into a mammalian somatic cell

摘要

A method for generating a nuclear reprogrammed cell in accordance with the present invention includes the step of: introducing, into a somatic cell, (i) at least one gene selected from the group consisting of a gene encoding histone H2aa or a homologue thereof, a gene encoding histone H2ba or a homologue thereof, and a gene encoding a phosphorylation-mimic form of histone chaperon Npm2 or a phosphorylation-mimic form of a homologue of Npm2, and (ii) a nuclear reprogramming factor.