One-Pot Synthesis of Dispiro[oxindole-3,3'-pyrrolidines] by Three-Component [3t2] Cycloadditions of in situ-Generated Azomethine Ylides with 3-Benzylidene-2,3-dihydro-1H-indol-2-ones

摘要

An efficient one-pot, three-component synthesis of novel dispiro[oxindole-3,3'-pyrrolidines] by 1,3- dipolar cycloaddition of azomethine ylides, in situ generated by reaction of 1,2-diones with sarcosine and subsequent decarboxylation, with a series of (E)-3-benzylidene-2,3-dihydro-1H-indol-2-ones is reported. Molecular complexity is generated in only one synthetic step. All reactions proceed with excellent regioselectivity and in good-to-excellent yields. The workup is easy, the reaction times are short, and no catalyst is required.