Regioselective [3+3] cyclization of 1,3-Bis(silyloxy)buta-1,3-dienes with 1,1,1-Trifluoro-4-(silyloxy)alk-3-en-2-ones: New and Convenient synthesis of functionalized 5-alkyl-3-(trifluoromethyl)phenols

摘要

Functionalized 5-alkyl-3-(trifluoromethyl)phenols were prepared by formal [3+3] cyclization of 1,3-bis(silyloxy)buta-1,3-dienes with 1,1,1-trifluoro-4- (silyloxy)alk-3-en-2-ones derived from 1,1,1-trifluoroalkane-2,4-diones. The latter were prepared by condensation of the dianion of 1,1,1-trifluoropentane-2, 4-dione with alkyl halides.