Comparison of endometrial intraepithelial neoplasia with WHO endometrial hyperplasia classification system. A comparative study of 150 cases.

摘要

Endometrial hyperplasia is a common disease. The wide range of histopathological presentations of endometrial hyperplasia is accompanied by high intra- and interobserver variability in diagnostic classification. The World Health Organization (WHO) (1994) classification of endometrial hyperplasia is plagued by poor diagnostic reproducibility and suboptimal prognostic prediction, particularly with regard to the presence or absence of cytological atypia.1 The fixed concept of cytological 'atypia' does not accommodate changes in cytology caused by the ambient hormonal state. Since 1961 many classifications of endometrial hyperplasia have been made and in 1994, to overcome confusion and controversy, the WHO formulated a new classification.