Hepatic sinusoidal obstruction syndrome reduces the effect of oxaliplatin in colorectal liver metastases

摘要

Sir. We read with interest the above paper by Vreuls et ah, which demonstrates that there is a statistically significant correlation between high-grade sinusoidal obstruction syndrome (SOS) and a failure to respond to oxaliplatin-based chemotherapy. This important finding strengthens the results of Tamandl et al., who reported that the presence of SOS was associated with poorer disease-specifier survival, althogh it was difficult to draw any useful conclusions from this study based on the small numbers reported.