A phase IIIb study of ledipasvir/sofosbuvir fixed-dose combination tablet in treatment-na < ve and treatment-experienced Korean patients chronically infected with genotype 1 hepatitis C virus

Lim Young-Suk; Ahn Sang Hoon; Lee Kwan Sik; Paik Seung Woon; Lee Youn-Jae; Jeong Sook-Hyang; Kim Ju-Hyun; Yoon Seung Kew; Yim Hyung Joon; Tak Won Young; Han Sang-Young; Yang Jenny C.; Mo Hongmei; Garrison Kimberly L.; Gao Bing; Knox Steven J.; Pang Phillip S.; Kim Yoon Jun; Byun Kwan-Soo; Kim Young Seok; Heo Jeong; Han Kwang-Hyub

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A phase IIIb study of ledipasvir/sofosbuvir fixed-dose combination tablet in treatment-na < ve and treatment-experienced Korean patients chronically infected with genotype 1 hepatitis C virus

机译：ledipasvir / sofosbuvir固定剂量联合片剂的IIIb期研究在初治和经验丰富的韩国慢性感染基因1型丙型肝炎患者中的应用

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The standard-of-care regimen for chronic hepatitis C virus (HCV) infection in Korea, pegylated-interferon-alpha plus ribavirin, is poorly tolerated. Ledipasvir/sofosbuvir is a two-drug, fixed-dose combination tablet approved in the USA, European Union, and Japan for chronic genotype 1 HCV infection.

机译：在韩国，慢性丙型肝炎病毒（HCV）感染的标准护理方案聚乙二醇化干扰素-α加利巴韦林耐受性差。 Ledipasvir / sofosbuvir是一种二药，固定剂量组合片剂，已在美国，欧盟和日本批准用于慢性基因型1 HCV感染。

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《Hepatology international》 |2016年第6期|共9页
作者
Lim Young-Suk; Ahn Sang Hoon; Lee Kwan Sik; Paik Seung Woon; Lee Youn-Jae; Jeong Sook-Hyang; Kim Ju-Hyun; Yoon Seung Kew; Yim Hyung Joon; Tak Won Young; Han Sang-Young; Yang Jenny C.; Mo Hongmei; Garrison Kimberly L.; Gao Bing; Knox Steven J.; Pang Phillip S.; Kim Yoon Jun; Byun Kwan-Soo; Kim Young Seok; Heo Jeong; Han Kwang-Hyub;
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正文语种 eng
中图分类消化系及腹部疾病;
关键词
Genotype 1; Hepatitis C virus (HCV); Korea; Ledipasvir; Sofosbuvir;

机译：基因型1;丙型肝炎病毒（HCV）;韩国;莱迪帕韦;索非布韦;

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1. A phase IIIb study of ledipasvir/sofosbuvir fixed-dose combination tablet in treatment-na < ve and treatment-experienced Korean patients chronically infected with genotype 1 hepatitis C virus [J] . Lim Young-Suk, Ahn Sang Hoon, Lee Kwan Sik, Hepatology international . 2016,第6期

机译：ledipasvir / sofosbuvir固定剂量联合片剂的IIIb期研究在初治和经验丰富的韩国慢性感染基因1型丙型肝炎患者中的应用
2. Ledipasvir/sofosbuvir fixed-dose combination tablet in Taiwanese patients with chronic genotype 1 hepatitis C virus [J] . Chuang Wan-Long, Chien Rong-Nan, Peng Cheng-Yuan, Journal of gastroenterology and hepatology . 2016,第7期

机译：Ledipasvir / sofosbuvir固定剂量联合用药治疗台湾地区慢性基因1型丙型肝炎病毒患者
3. A phase 3b study of sofosbuvir plus ribavirin in treatment-naive and treatment-experienced Korean patients chronically infected with genotype 2 hepatitis C virus [J] . Ahn S. H., Lim Y. S., Lee K. S., Journal of viral hepatitis. . 2016,第5期

机译：索非布韦联合利巴韦林在未接受治疗和有治疗经验的韩国慢性感染基因2型丙型肝炎患者中的3b期研究
4. Genotype and Serotype Identification of Hepatitis B Virus in Chronic Hepatitis B Patients Treated with Telbivudine [C] . Y Purnamasari, Tien, Arimaswati, International Seminar on Smart Molecule of Natural Resources . 2020

机译：临床治疗慢性乙型肝炎患者乙型肝炎病毒的基因型和血清型鉴定
5. An exploratory study for the discovery of non-invasive hepatocellular carcinoma biomarkers among high-risk hepatitis C virus infected patients. [D] . Abdalla, Moemen. 2009

机译：在高危丙型肝炎病毒感染患者中发现非侵入性肝细胞癌生物标志物的探索性研究。
6. Naturally Occurring Mutations in the Nonstructural Region 5B of Hepatitis C Virus (HCV) from Treatment-Naïve Korean Patients Chronically Infected with HCV Genotype 1b [O] . Dong-Won Kim, Seoung-Ae Lee, Hong Kim, -1

机译：来自未接受过治疗的韩国慢性感染HCV基因型1b的韩国患者的丙型肝炎病毒（HCV）非结构区5B的自然突变
7. Sofosbuvir and Ledipasvir/Sofosbuvir for the treatment of patients with Chronic Genotype 6 Hepatitis C Virus Infection: integrated analysis of Phase 2 and Phase 3 studies [O] . Chuang, WL, Gane, EJ, Hyland, RH, 2015

机译：sofosbuvir和Ledipasvir / sofosbuvir用于治疗慢性基因型6型丙型肝炎病毒感染患者：2期和3期研究的综合分析

A phase IIIb study of ledipasvir/sofosbuvir fixed-dose combination tablet in treatment-na < ve and treatment-experienced Korean patients chronically infected with genotype 1 hepatitis C virus

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