Investigation of serum tumor markers in the diagnosis of gastric cancer.

摘要

BACKGROUND/AIMS: The purpose of this study was to evaluate the value of the tumor marker biochip C12 system in gastric cancer. METHODOLOGY: A retrospective study of 183 patients with gastric cancer undergoing resection of gastric carcinoma was performed. Correlations between tumor markers and clinicopathologic features were evaluated univariately and multivariately. The most beneficial combination of key tumor markers in gastric cancer diagnosis was selected using chi-squared test. RESULTS: The total positive rate of tumor markers for patients with gastric cancer was 42.6%. Multivariate logistic regression analysis revealed that the serum result of CA19-9 and CA125 were correlated with N stage, the serum result of CA242 was correlated with T stage and N stage, while the serum result of CEA was correlated with clinical stage and tumor histological differentiation (p < 0.05). Combinations of three tumor markers with high positive rates were CA242 + CEA + CA19-9 and CA242 + CEA + CA125, positive rates of which were 35.0% and 34.4% respectively with no statistical significance compared with twelve tumor markers combination (chi-squared test, p > 0.05). CONCLUSION: The tumor marker biochip system has important diagnostic value in gastric cancer. CA19-9, CA242, CEA and CA125 were four key markers in tumor diagnosis.