Basic Fibroblast Growth Factor Enema Improves Experimental Colitis in Rats

摘要

Background/Aims: Growth factors have a potential role in gastrointestinal mucosal repair. Although basic fibroblast growth factor (b FGF) is known to contribute to wound healing, however, the role of b FGF in the treatment of inflammatory bowel disease has not been established. The aim of this study is to investigate the therapeutic effects of intra-colonic b FGF administration on both the clinical symptoms and histological mucosal repair in an experimental model of colitis in rats Methodology: Acute colitis was induced with 5% dextran sulfate sodium (DSS) given for one week in drinking water. The rats were treated daily with recombinant human b FGF enema (400mug/kg/day) orvehicle once daily from day 1 to day 7. Clinical score (stool consistency, weight loss and hemoccult/gross rectal bleeding), colon length and histological score of mucosal injury in colonic tissue samples were analyzed.Results: Administration of b FGF enema significantly reduced clinical score (p<0.01) and histological score (p<0.01). No specific side effect of b FGF was noted Conclusions: These results suggest that b FGF enema is clinically safe and useful in the treatment of inflammatory bowel disease. BFGF enema may contribute as a novel therapy of IBD.