Pharmacokinetics of carbon nanoparticle-paclitaxel suspension for use in intraperitoneal chemotherapy

摘要

Background/Aims: To study the pharmacokinetics of carbon nanoparticle-paclitaxel suspension (CNPS) in intraperitoneal chemotherapy. Methodology: Thirty-three Wistar rats were randomly assigned to an experimental group (A) and a control group (B), to which intraperitoneal injections of CNPS and paclitaxel were administered, respectively. At time points ranging from 10 min to 7 days, we measured the concentration of paclitaxel in blood, mesenteric lymph nodes and peritoneal lavage. Results: The ratio of the area under the curve (AUC) in plasma of group A to that of group B was 0.6263. The ratio of AUC in lymph nodes of group A to group B was 0.7495 and that in peritoneal lavage was 1.25. The metabolic half-life of paclitaxel (t1/2) in plasma of group A was 1.607 times as long as that of group B. The t1/2 of paclitaxel in peritoneal lavage of group A was 0.879 as long as that of Group B. The t1/2 of paclitaxel in lymph nodes of group A was 1.097 as long as that of Group B. Conclusions: Intraperitoneal chemotherapy by CNPS was characterized by low drug concentration in blood, high drug concentration in peritoneal and high security, but lack of significant lymph targeting and lymphatic retention effect.