Direct Asymmetric anti-Mannich-Type Reactions Catalyzed by Cinchona Alkaloid Derivatives

摘要

Aseries of cinchona alkaloid derivatives were used to catalyze the asymmetric anti-Mannich-type reaction of 3-methyl-2-oxindole with N-tosyl aryl aldimines. The resulting anti-3, 3-disubstituted 2-oxindole products were obtained in good yields (up to 92%) with high diastereoand enantioselectivities (anti/syn up to 97:3 and 91% ee).