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首页> 外文期刊>Chirality: The pharmacological, biological, and chemical consequences of molecular asymmetry >Solving multicomponent chiral separation challenges using a new SFC tandem column screening tool
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Solving multicomponent chiral separation challenges using a new SFC tandem column screening tool

机译:使用新型SFC串联色谱柱筛选工具解决多组分手性分离难题

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摘要

A tool for improved tandem column chiral supercritical fluid chromatography (SFC) method development screening was prepared by modification of a commercial analytical SFC instrument with two different software-controllable, six position high-pressure column selection valves, each controlling a bank of five different columns and a pass through line. The resulting instrument, which has the ability to screen 10 different individual columns and 25 different tandem column arrangements, is a useful tool for facilitating the screening of tandem column SFC arrangements for separation of complex mixtures of stereoisomers or other multicomponent mixtures. Strategies for optimal use of the instrument are discussed, and several examples of the use of the instrument in developing tandem SFC methods for resolution of multicomponent mixtures are presented. (c) 2006 Wiley-Liss, Inc.
机译:通过使用两个不同的软件控制的,六个位置的高压色谱柱选择阀对商业分析型SFC仪器进行改造,制备了用于改进串联色谱柱手性超临界流体色谱(SFC)方法开发筛选的工具,每个阀控制五个不同的色谱柱和一条通过线。所得到的仪器具有筛选10种不同的独立色谱柱和25种不同的串联色谱柱排列的能力,是一种有助于筛选用于分离立体异构体的复杂混合物或其他多组分混合物的串联色谱柱SFC排列的有用工具。讨论了仪器最佳使用的策略,并介绍了在开发串联SFC方法用于分离多组分混合物时使用仪器的几个示例。 (c)2006年Wiley-Liss,Inc.

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