Postoperative analgesic effects of intravenous, intramuscular, subcutaneous or oral transmucosal buprenorphine administered to cats undergoing ovariohysterectomy.

摘要

Objective: To compare the postoperative analgesic effects of intravenous (IV), intramuscular (IM), subcutaneous (SC) or oral transmucosal (OTM) buprenorphine administered to cats undergoing ovariohysterectomy. Study design: Randomized, prospective and blinded clinical trial. Animals: 100 female cats. Methods: Cats were assigned to receive 0.01 mg kg-1 of buprenorphine administered by the IV, IM, SC or OTM route (n=25/group). Buprenorphine was made up to 0.3 mL with 0.9% saline. DIVAS (0-100 mm) and simple descriptive scale (SDS) (from 0 to 4) pain and sedation scores were assigned to each cat before and 1, 2, 3, 4, 6, 8, 12 and 24 hours after ovariohysterectomy. Buprenorphine and carprofen were administered for rescue analgesia. Data were analyzed using ANOVA and Fisher's exact test (p<0.05). Results: There were no significant differences between groups for breed, body weight, anesthetic time or surgery time (p