Targeting TNF-a receptors for neurotherapeutics

摘要

In this section we describe how a single ligand, TNF-a, can act in different regions of the brain in multiple ways to control a diverse array of physiological processes; an in-depth understanding of the underlying signaling mechanisms might facilitate our ability to selectively control discrete aspects of TNF-a function. The production and secretion of inflammatory cytokines are processes associated with both neuronal and peripheral immunity. The CNS possesses its own immune system which includes microglia. When activated, microglia secrete multiple factors that can ensure neuronal survival, but are also able to initiate apoptosis of fatally damaged neurons through the secretion and production of inflammatory precursors such as TNF-alpha .