Thermal gelation of aqueous hydroxypropylmethylcellulose solutions with SDS and hydrophobic drug particles

摘要

The thermal gelation of hydroxypropylmethylcellulose (HPMC) solutions has been studied as a function of sodium dodecyl sulfate (SDS) concentration with and without griseofulvin, a model particulate BCS Class II drug by Theological measurements of gelation temperature (T_(gel)), steady-state viscosity (η) at 25 °C, and ξ-potential. Polymer adsorption on the drug was demonstrated by a decrease in η and potential in the absence of SDS. Griseofulvin had a synergistic effect on gelation which was attributed to an effective spanning of associated hydrophobic polymeric regions through interactions with the adsorbed polymer. Adding SDS offsets this effect on T_(gel) shielding hydrophobic interactions. Higher SDS concentrations had no effect on the particles surface as evidenced by constant ξ-potential and T_(gel). Yet, polymeric chains are saturated and larger surfactant aggregates account for the increase in viscosity. Understanding the gelation mechanism and complex interactions of HPMC with surfactants and drugs is necessary for the design of pharmaceutical products and optimization of their performance properties.