The effects of propofol and a diazepam/alfentanil combination in dogs aged 10 years and above on heart rate, respiratory rate, pulse oximetry data, intraocular pressure, and body temperature

摘要

In older patients, it is important to minimise anaesthesia-related deaths and complications. In this study, 2 separate anaesthesia inductions were evaluated with respect to their effects on heart rate, respiratory rate, pulse oximetry data, intraocular pressure, and body temperature. A total of 22 dogs were evaluated and 2 separate anaesthesia groups were formed. Propofol (6 mg/kg) was administered to group Gl via a slow intravenous (IV) injection. In group G2, diazepam (0.5 mg/kg) was first administered via an TV injection, followed immediately by alfentanil (40 ug/kg), administered via a slow IV route. Each parameter was recorded prior to anaesthesia (T ), immediately after anaesthesia induction (min 0-Tj), 5 min after induction (T2), immediatelyafter intubation (min 0-T3), and 5 min after intubation (T4). Statistical analysis was performed by repeated measurements of ANOVA and independent samples t-test methods in SPSS 10.0. While no difference was observed between the times of measurements ingroup Gl regarding heart rate, respiratory rate, and pulse oximetry data, differences were determined between the measurement times in group G2. In group Gl, a drop occurred in intraocular pressure immediately after anaesthesia induction. In group G2, adecrease in intraocular pressure was observed in the measurement taken 5 min after induction. Body temperature dropped significantly in both groups. It was concluded that, in the anaesthesia induction of patients aged 10 years and above, propofol, with more reliable findings, should be preferred over the diazepam/ alfentanil combination.