Association of ABO Blood Groups with Lipid Profile and the Level of Oxidative Stress in Hypertensive Patients

摘要

A case control study was undertaken to find out a possible relationship of ABO blood groups with serum triglyerides (TGs), total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), very low density lipoprotein cholesterol (VLDL-C) and the level of oxidative stress in 60 patients with essential hypertension (SBP > 140, DBP > 90) of age group between (45 - 65 years) which were compared with 60 normal healthy controls. The results showed significantly elevated levels serum TGs, TC, LDL-C and VLDL-C and lipid peroxide (LPO) content in patients with antigen A and B (B+AB) along with decreased levels of HDL-C. A significant positive correlation between serum TGs and TC with LPO was observed in groupA (r=0.62, P<0.01; r=+0.52., P<0.05), B (r=+0.28, P<0.10; r=+0.46, P<0.05) and AB patients (r =+0.18, P<0.10; r=+0.28, P<0.10 ).The study emphasizes that the patients with blood group A, B and AB are more susceptible to oxidative stress compared to thatof group O due to the presence of specific carbohydrate molecules on the red cell antigens of blood group A & B which may impair the metebolism of lipids in blood. Elevated blood pressure and rapid blood flow may increase the lipid oxidation and peroxidation reactions resulting in increased oxidative stress in them.