Two faces of BRD4:Mitotic bookmark and transcriptional lynchpin

摘要

The bromodomain protein BRD4 links cell cycle and transcription, bookmarking active genes during mitosis and serving as a scaffold for transcription factors. Our recent discovery that BRD4 is a RNA polymerase II CTD kinase identifies a novel transcriptional function. Here we discuss our model in the context of current knowledge.