Chromatin modification by the RNA Polymerase IIelongation complex

摘要

Transcription elongation by RNA polymerase II (RNAP II) involves the coordinated action of numerous regulatory factors. Among these are chromatin-modifying enzymes, which generate a stereotypic and conserved pattern of histone modifications along transcribed genes. This pattern implies a precise coordination between regulators of histone modification and the RNAP II elongation complex. Here I review the pathways and molecular events that regulate co-transcriptional histone modifications. Insight intothese events will illuminate the assembly of functional RNAP II elongation complexes and how the chromatin landscape influences their composition and function.