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Clinical and Laboratory Diagnosis of Inherited Platelet Function Disorders

机译:遗传性血小板功能障碍的临床和实验室诊断

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摘要

In the present issue of Transfusion Medicine and Hemother-apy current strategies for the diagnosis of inherited platelet function disorders that have been established in different clinics in the German-speaking countries are summarized. These strategies are partially related to diagnostic algorithms applied in Italy or the UK [1, 2]. Inherited platelet function disorders represent a heterogeneous group of hemostaseologic diseases with predominantly mild to moderate bleeding symptoms. Very often a platelet function defect is not recognized in the newborn due to the mild symptoms. However, in the adolescent age bleeding complications such as menorrhagia or prolonged bleeding after injuries or tooth extraction may occur. Thus the correct incidence, especially of platelet function disorders with mild bleeding, is still unclear. The development and application of diagnostic algorithms is an important prerequisite to improve the identification and subsequent treatment of inherited platelet disorders.
机译:在本期《输血医学》和《 Hemother-apy》中,总结了在德语国家/地区的不同诊所中建立的用于诊断遗传性血小板功能障碍的当前策略。这些策略部分与意大利或英国[1,2]中应用的诊断算法有关。遗传性血小板功能障碍代表了一组不同的止血病疾病,主要表现为轻度至中度出血症状。由于症状较轻,通常在新生儿中未发现血小板功能缺陷。但是,在青春期,可能会发生出血并发症,例如月经过多或受伤或拔牙后出血时间延长。因此,尚不清楚正确的发病率,尤其是血小板功能障碍伴轻度出血的发病率。诊断算法的开发和应用是改善遗传性血小板疾病的鉴定和后续治疗的重要前提。

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