Severe neonatal alloimmune thrombocytopaenia with anaemia.

摘要

Foetaleonatal alloimmune thrombocytopaenia (FNAIT) accounts for 3% of all foetal and neonatal thrombocytopaenias and for 27% of severe cases. It arises from the destruction of foetal platelets by maternal immunoglobulin G (IgG) antibodies against antigens inherited from the father which the mother is lacking (Kaplan, 2008). Its clinical relevance subsides in the increased risk of intracranial haemorrhage (ICH) (20-30% of reported cases) which leads to death (10%) or neurological sequelae (20%). It has also been reported that 80% of ICH associated with FNAIT occur in utero, with 14% occurring before 20 weeks, 28% occurring before 30 weeks and that may be related with neurological sequelae (Burrows et ah, 1988).