Synthesis, characterization and antibacterial activities of manganese(II), cobalt(II), nickel(II), copper(II) and zinc(II) complexes with soluble vitamin K_3 thiosemicarbazone

摘要

A thiosemicarbazone derivative of the Vitamin K_3 has been synthesized. Five transition metal complexes of the thiosemicarbazone have been prepared and characterized by i.r., u.v.-vis, molar conductance and thermal analyses. All of the complexes possess strong inhibitory action against G(+) Staphylococcus aureus, G(-) Hay bacillus, and G(-) Eschericha coli. The antibacterial activities of the complexes are stronger than those of the thiosemicarbazone itself.