首页> 外文期刊>Translational research: the journal of laboratory and clinical medicine >Monocytes to functional dendritic cells is often a bridge too far for cancer therapy.
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Monocytes to functional dendritic cells is often a bridge too far for cancer therapy.

机译:单核细胞与功能性树突状细胞通常是癌症治疗的桥梁。

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摘要

Interferons are a class of proinflammatory cytokines with important immunologic functions, especially in regard to host defense against viral infections. Interferons are also unique cytokines in their ability to be produced by and to activate numerous cell types, of both hematopoietic and stromal origin. For example, interferons stimulate the activation of immune cells through the upregulation of major histocompatibility complex (MHC) molecules, promoting antigen presentation and lymphocyte activation. In addition, interferon has potent antiproliferative/proapoptotic effects, and it can signal many cell types to degrade messenger RNA and limit protein synthesis, in an attempt to limit viral replication in infected (or potentially infected) cells.
机译:干扰素是一类具有重要免疫功能的促炎细胞因子,尤其是在宿主防御病毒感染方面。干扰素也是由造血和基质来源的多种细胞产生和激活的能力中的独特细胞因子。例如,干扰素通过主要组织相容性复合体(MHC)分子的上调刺激免疫细胞的活化,从而促进抗原呈递和淋巴细胞活化。此外,干扰素具有有效的抗增殖/促凋亡作用,它可以发出多种信号来降解信使RNA并限制蛋白质的合成,从而试图限制感染(或潜在感染)细胞中的病毒复制。

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