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首页> 外文期刊>Transactions of the Royal Society of Tropical Medicine and Hygiene >Beri-beri: the major cause of infant mortality in Karen refugees.
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Beri-beri: the major cause of infant mortality in Karen refugees.

机译:贝里贝里:卡伦难民婴儿死亡的主要原因。

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摘要

During a prospective evaluation of malaria prophylaxis in pregnancy in a refugee population on the north-western border of Thailand from 1987 to 1990, an extremely high infant mortality rate (18%) was documented despite good access to health care. Infantile beri-beri was recognized as the main cause of death accounting for 40% of all infant mortality. Thereafter, severe vitamin B1 deficiency in infants was diagnosed and treated promptly. The impact of this was assessed prospectively from 1993 to 1996 in a second cohort study. The case fatality of infantile beri-beri fell from almost 100% to 7%. The overall infant mortality rates declined from 183 to 78 per 1000 live births. Post-neonatal deaths fell by 79% (95% CI 65-87%) while neonatal mortality remained unchanged. Mortality resulting from acute respiratory infections did not change (15 and 11 per 1000, respectively), whereas mortality attributable to beri-beri decreased from 73 to 5 per 1000 (P < 0.0001). Before its recognition approximately 7% of all infants in this population died from infantile beri-beri. This lethal but preventable syndrome may be more common than hitherto recognized, particularly in refugee populations, in this populous region.
机译:在1987年至1990年对泰国西北边界的泰国难民中的预防疟疾的孕妇进行的前瞻性评估中,尽管获得了良好的医疗保健服务,但婴儿死亡率仍然很高(18%)。小儿贝里-贝里被认为是主要的死亡原因,占所有婴儿死亡率的40%。此后,对婴儿中严重的维生素B1缺乏症进行了诊断和及时治疗。从1993年到1996年,在第二项队列研究中前瞻性地评估了这一影响。婴儿贝里-贝里的致死率从几乎100%下降到7%。婴儿的总死亡率从每千名活产婴儿中的183下降到78。新生儿死亡率下降了79%(95%CI 65-87%),而新生儿死亡率保持不变。急性呼吸道感染导致的死亡率没有改变(分别为每千人15和11),而因贝里贝里引起的死亡率从每1000人中的73降低到5(P <0.0001)。在此之前,该人群中约有7%的婴儿死于婴儿贝里-贝里。这种致命但可预防的综合征可能比迄今为止公认的更为普遍,尤其是在这个人口稠密地区的难民中。

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