Hepatic and renal tissue selenium levels in a mouse model of candidiasis

摘要

Objective: Candidemia is a form of sepsis resulting in a complicated inflammatory response in living organisms. There is no sufficient data about selenium levels in candidiasis. Methods: Selenium levels were analyzed by atomic absorption spec-trophotometry in different organs of mouse model of candidiasis. Results: We found that selenium levels increased in hepatic tissue of the mice (1 045.9 +-166.29 ng/ml), while they decreased in renal tissue (518.48 +-258.18 ng/ml) when compared with control groups (p > 0.001). Conclusions: This can be explained by the different selenium uptake of the metabolic pathways in renal and hepatic tissues.