Role of 4G/5G promoter polymorphism of Plasminogen Activator Inhibitor-1 (PAI-1) gene in outcome of sepsis.

摘要

Serious infections trigger a systemic inflammatory response which results in sepsis. Severe sepsis is sepsis complicated by organ dysfunction and when sepsis results in hypotension despite adequate fluid resuscitation, it is called septic shock having a poor prognosis [1 ]. Even though significant advances, both in supportive care and in understanding its molecular bases, sepsis is the most common cause of death among patients in an intensive care unit (ICU) [2]. The innate immune system acts releasing cytokines and mediators that stimulate the adaptive immune responses although these are injurious to various tissues and organs [3]. It is possible that the persistence of high concentration of certain proinflammatory cytokines or the incapacity of raising certain cytokines at a specific moment might perpetuate the inflammatory response resulting in sepsis or septic shock [1-3].