A clinical-laboratory approach contributing to a rapid and reliable diagnosis of heparin-induced thrombocytopenia: An update.

摘要

We recently published a clinical-laboratory approach for the diagnosis of heparin-induced thrombocytopenia (HIT). Our study confirmed that the combination of the ID-heparin (H)/platelet factor 4 (PF4) PaGIA~R (Diamed, Cressier sur Morat, Switzerland) with the clinical 4 T's score is a reliable screening strategy to rule out or support rapidly the diagnosis of HIT. Yet, the flow cytometric measurement of the CD62p-expression (flowCD62p) remains necessary to confirm the presence of functional relevant antibodies in patients with clinical features of HIT, especially when the clinical situation is not straightforward (intermediate risk group). This combined diagnostic work-up is considered to have the advantage to contribute in a rapid and reliable way to the definite diagnosis of HIT.