Administration of antiprogestin J956 for contraception in bears: Apharmacological study

摘要

Effective and reversible control of reproduction in bears is highly desirable for conservation and management programs in zoos to establish genetically variable ex-situ populations of bears within the constraints of limited space in captivity. The reproductive physiology of bears is characterized by two main traits-seasonality and delayed implantation, which is progesterone dependent, This offers the opportunity to interrupt early pregnancy by short-term administration of antiprogestins.