With interest I have read the article of Aubert and colleagues on the prospective determination of serum ceftazi-dime (CAZ) concentrations in intensive care units (ICUs). The authors conclude their article by stating that CAZ measurement is needed in ICUs to achieve adequate CAZ concentrations to reach optimal efficacy and minimal toxicity. I agree with the authors that in an ideal world, it would be great to have an opportunity to optimize our treatment by measuring the concentration of a drag used if there is a clear relationship between the pharmacokinetics and phar-macodynamics of the drug as clearly is the case in the treatment of many infectious diseases. However, in the case of CAZ, an antibacterial agent purely cleared by glomerular filtration rate (GFR), the question arises whether it would have been much easier to measure GFR than to measure CAZ.
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