Anti-Skin Tumor Activity of Nutraceuticals from Strawberry, Coriander, Red Coral Lettuce and Chinese Chives

摘要

As part of the continuing validation of nutraceuticals with previously reported antioxidant activityin preventing chemically induced skin tumors, the anti-skin tumor activity of strawberry fruits andthe leaves of coriander, red coral lettuce and Chinese chives were evaluated using the mouseskin tumor assay with dimethylbenz[a]anthracene (DMBA) as tumor initiator and croton oil astumor promoter. Coriander effectively blocked the initiation of tumors but failed to suppress thetumor promotion stage. In contrast, strawberry was effective against the tumor promotion stagebut was inactive against the tumor initiation step. Chinese chives effectively blocked both thetumor initiation and tumor promotion stages. Red coral lettuce was more effective when applied1 h prior to croton oil while Chinese chives were more potent when applied immediately aftercroton oil. These nutraceuticals showed evidence of being chemopreventors and/or anti-tumorpromoters. However, in all cases, the nutraceuticals did not stop the proliferation of skin tumors,once initiated and promoted, leading to skin tumor multiplicity.