Pharmacokinetics of enrofloxacin and its metabolite ciprofloxacin in goats given enrofloxacin alone and in combination with probenecid

摘要

The pharmacokinetics of enrofloxacin and its active metabolite ciprofloxacin were investigated in goats given enrofloxacin alone or in combination with probenecid. Enrofloxacin was administered i.m. at a dosage of 5 mg.kg(-1) alone or in conjunction with probenecid (40 mg.kg(-1), i.v.). Blood samples were drawn from the jugular vein at predetermined time intervals after drug injection. Plasma was separated and analysed simultaneously for enrofloxacin and ciprofloxacin by reverse-phase high performance liquid chromatography. The plasma concentration-time data for both enrofloxacin and ciprofloxacin were best described by a one-compartment open pharmacokinetic model. The elimination half-life area under the plasma concentration-time curve (AUC), volume of distribution mean residence time (MRT) and total systemic clearance (Cl-B) were 1.39 h, 71.82 mug.h.mL, 1.52 L.kg(- 1), 2.37 h and 802.9 mL.h(-1).kg(-1), respectively.