Use of an avirulent live Salmonella Choleraesuis vaccine to reduce the prevalence of Salmonella carrier pigs at slaughter

摘要

Salmonella tnterica is one of the major foodborne pathogens transmitted by pork; and a decrease in the number of carrier pigs at slaughter is considered to be the first step in achieving Salmonella-bee pork products. Vaccination may be a viable approach for shortening the time required to decrease the number of herds with a high infection rate through increasing resistance to Salmonella in susceptible pigs. The SC-54 attenuated strain of Salmonella enterica serovar Choleraesuis var Kurzendorf was obtained after repeated passages of a virulent strain in pig neutrophiIs; resulting in the loss of the spv gene from the virulence plasmid. Trials conducted on artificially inoculated pigs demonstrated that this strain is safe and able to protect animals from infection. This study evaluated the use of the vaccine produced with the SC-54 strain in a herd with a high prevalence of Salmonella, with the aim of reducing the number of Salmonella carriers at slaughter.