Efficacy of a Salmonella Typhimurium and Salmonella Choleraesuis experimental combination vaccine against S. Typhimurium and S. Choleraesuis challenges in growing pigs

摘要

Salmonella enterica serovar Typhimurium {ST) and Salmonella enterica serovar Choleraesuis (SC) are primary pathogens in swine. ST is a primary cause of enteritis and subclinical production losses in growing or finishing swine and contributes to environmental and carcass contamination. SC is a primary cause of septicemia, pneumonia and/or enterocolitis in growing pigs. SC vaccines are commercially available and some have been reported to demonstrate cross-protection against ST.1 However, no vaccines are currently available that combine both ST and SC to specifically target clinical disease of both Salmonella Typhimurium and Salmonella Choleraesuis. Reducing clinical signs of Salmonellosis caused by both ST and SC and shedding of ST, specifically, would be advantageous to swine producers. The objectives of these studies were to evaluate the efficacy of an experimental combination Salmonella Typhimurium and Salmonella Choleraesuis, Avirulent Live Culture (ALC) vaccine, as an aid in the prevention of Salmonellosis caused by virulent Salmonella Choleraesuis and a virulent Salmonella Typhimurium.