CrossTalk opposing view: The late sodium current is not an important player in the development of diastolic heart failure (heart failure with a preserved ejection fraction)

摘要

Diastolic heart failure (also referred to as heart failure with preserved ejection fraction (HFpEF)) is considered when the signs and symptoms of heart failure develop in response to left ventricular (LV) diastolic dysfunction without a significant decrease in the LV ejection fraction (McMurray et al. 2012). Currently, questions outweigh answers for the molecular background of HFpEF, mostly because the clinical picture of HFpEF is complicated by co-morbidities, various haemodynamic conditions, and uncertain therapeutic interventions. Nevertheless, demographic and preclinical investigations now implicate roles for hypertension, obesity, diabetes, and concentric LV hypertrophy in the pathophysiology of HFpEF (Edelmann et al. 2011; Shah & Solomon, 2012; Paulus & Tschope, 2013).