CrossTalk opposing view: Peripheral and central chemoreflexes have additive effects on ventilation in humans

摘要

How else could the central-peripheral interaction be tested? Human experiments are often non-invasive. Consequently, differences in chemoreflex response times are frequently used to separate the central and peripheral components. An early experiment of this sort by Robbins (1988) concluded that central-peripheral interaction was more than additive. However, the same protocol was repeated by St Croix et al. (1996), who concluded that in four of the five subjects studied no interaction was evident. In similar experiments involving exercise it was concluded that a central-peripheral interaction was absent (Clement et al. 1992) because the dynamics of the peripheral and central