Randomized controlled trial on weight loss in obstructive sleep apnea: inappropriate analysis limits main conclusion.

摘要

The randomized controlled trial by Tuomilehto et al (1) in a recent issue of the Journal has provided much-needed insight into the long-term effects of a weight-loss program on mild obstructive sleep apnea in overweight and obese adults. Nevertheless, we are concerned about the robustness of the main conclusion, that weight loss improves obstructive sleep apnea, mainly due to a flawed intention-to-treat analysis. Two suggestions for how the authors may improve their analysis are provided here.