Antiangiogenic therapy in metastatic prostate carcinoma complicated by cutaneous lupus erythematodes

摘要

A 61-year-old man was diagnosed with progressive hormone-refractory prostate cancer complicated by paraneoplastic subacute cutaneous lupus erythematodes (SCLE). The first diagnosis of prostate carcinoma was made in March, 1995, by prostatectomy. liver metastases were first diagnosed in January, 2002. From April, 2002, to November, 2003, the patient received 75 mg/m~2 docetaxel every 21 days. In November, 2003, the patient presented with well-demarcated, raised erythematous macules and plaques with pityriasic scales and hyperaesthesia on the arms and trunk (figure 1). Histopathological assessment confirmed the clinical diagnosis of SCLE (figure 2). Direct immunofluorescence of involved skin was positive with a band-like deposition of immunoglobulins (IgG, IgM) and C3. We recorded no serum antibodies against double stranded DNA, Ro-SSA, or La-SSB.