Selective androgen receptor modulators in cancer cachexia?

摘要

Although osteoporosis has been a dominant target for novel therapeutics for the past two decades, much interest now surrounds that other component of the musculoskeletal system, namely skeletal muscle. This interest has been spurred by increased understanding of the molecular biology of skeletal muscle fuelled partly by the nascent science of sports medicine. Equally a strong imperative exists for such research in view of the daunting demographics of age-related sarcopenia. Adults older than 40 years lose 1% of their muscle mass per year; the number of individuals olderthan 80years is projected to double over the next 20 years and in this population age-related muscle loss is predicted to be a major source of physical disability, poor quality of life, and death.