Peripartum changes in plasma estrone sulfate and estradiol-17 beta profiles associated with and without the retention of fetal membranes in Holstein-Friesian cattle.

摘要

The aim of this study was to evaluate the changes in plasma concentrations of estrone sulfate (E1S) and estradiol-17 beta (E2 beta ) during the peripartum period (from day 10 prepartum to day one postpartum) associated with and without retention of fetal membranes (RFM) in Holstein-Friesian cattle (n=42). Plasma samples were analysed for E1S and E2 beta by ELISA. All parturitions were spontaneous and normal. Of the 38 cattle that delivered singletons, 29 had no RFM (singleton-normal group) and 9 had RFM for more than 12 h (singleton-RFM group). Four cows gave birth to twins, and each twin had its own fetal membrane (FM). Two twinning cows expelled both FMs normally within 12 h (twin-normal group). In the remaining 2 twinning cows (twin-RFM group), the FM was expelled normally for one twin (first), whereas the FM of the other (second) was retained. Insignificant differences in the E1S concentrations or their increments from the concentrations on the preceding day were observed between the normal and RFM groups of singleton cows on any peripartum day. The mean plasma E2 beta concentrations on each day from days 10-3 prepartum were significantly lower (P<0.05) in the singleton-RFM group compared to that in the singleton-normal group. However, on days two and one prepartum, the increments in the E2 beta concentrations from the concentrations on the preceding days were significantly higher (P<0.05) in the singleton-RFM group than in the singleton-normal group. Thus, the plasma E1 beta concentrations just before parturition might not be associated with RFM. In the cows with RFM, the lower plasma E2 beta concentrations that were found prior to day 2 prepartum might have been associated with immature placentomes, and the rapid rise in plasma E2 beta within 1-2 days prior to calving might have produced asynchrony of placental and/or fetal maturation in relation to calving, thus resulting in RFM..