Temporal Lobe Meningioma With Ipsilateral Herpes Simplex Encephalitis

摘要

An 87-year-old woman presented with subacute onset of headache, fever, and episodes of aphasia, eventually progressing to coma. Magnetic resonance imaging (MRI) revealed a newly identified enhancing left sphenoid wing meningioma with peritumoral edema in the underlying brain (Figure 1). MRI also demonstrated expansile fluid-attenuated inversion recovery (FLAIR) signal, restricted diffusion, and elevated plasma volume in the medial temporal lobe more suggestive of superimposed infection. Electroencephalogram (EEG) showed left periodic lateralized epileptiform discharges (PLEDS). Cerebrospinal fluid (CSF) analysis showed herpes simplex virus 1 (HSV1) by polymerase chain reaction (PCR). Despite treatment with intravenous acyclovir, the patient remained comatose and comfort measures were pursued. Herpes encephalitis has been described in the setting of cancer and brain metastases but not concurrently with meningioma.1'2 Postmortem examination confirmed HSV1 and meningioma (Figure 2).