Progesterone and Preterm Birth

摘要

to the editor: The reports by Fonseca et al. and Rouse et al. (Aug. 2 issue) raise important issues regarding the efficacy and safety of proges-tins for the prevention of preterm birth. An essential difference between the two study designs is that the study by Fonseca et al. evaluated progesterone administration for a defined pathologic condition, premature cervical shortening, and the the study by Rouse et al. assessed treatment for a risk factor, twin pregnancy