Microcirculatory responses to hypovolemic shock.

摘要

The main role of the microcirculatory network is to allow I the exchange of molecules between blood and tissue. Particularly, the exchange of oxygen, carbon dioxide, nutrients, hormones, cytokines, waste products, and heat takes place between circulating blood and parenchymal cells. Adequate blood flow within the microvascular network is an essential prerequisite for normal organ perfusion and function which determines normal hemodynamic conditions of the living organisms. Under shock conditions regardless of the resuscitation undertaken, microcirculatory abnormalities are known to persist long after successful patient resuscitation as assessed by central hemodynamic parameters. These abnormalities may be a major contributing factor to the development of postshock multiorgan dysfunction syndrome. Thus, microcirculatory network may be considered as special vital organ of cardiovascular system which functions to ensure adequate delivery of oxygen to various tissues and as a result, becomes a subject of interest to many investigators interested in improvement of hypovo-lemic shock treatment.