The preparative chromatographic enantioseparation of a racemic morphanthridine analog on a chiral stationary phase

摘要

The preparative chromatographic enantioseparation of a chiral morphanthridine analog has been performed on an analytical column using amylose-tris(3,5-dimethylphenylcarbamate) as chiral stationary phase. The racemate (100 mg) was resolved to baseline within 15 min. This paper describes the development of the method, estimation of the capacity of the chiral stationary phase and discusses the potential of the chromatography if performed under preparative conditions. From the results and calculations presented it seems likely that the resolution of 70 tons year(-1) could easily be achieved on 30 kg of stationary phase with a mobile-phase consumption of only 720 L day(-1). [References: 12]