Management and control of modifier content in preparative SFC solvent cycles

摘要

The objective of this work was to establish a solvent cycle with a possibility for modifier control in a preparative supercritical fluid chromatography simulated moving bed plant(SFC-SMB).Fourier transform infrared(FTIR)spectroscopy and flame ionization detection(FID)have been investigated for measuring alcohol concentrations in supercritical carbon dioxide.The integration of these in-line techniques into a modifier control schema allowed the operation of a closed loop SFC-SMB cycle.The applicability of the developed control concept for usage of 2-propanol in supercritical carbon dioxide has been verified by an experimental test series involving an eight column SFC-SMB plant.Different process variations have been compared in terms of energy and solvent consumption.Hereby,savings of almost all CO2 and 76% modifier could be achieved.